Kuby Immunology 7th Edition By Judith A. Owen – Test Bank

Chapter 11 T-Cell Activation, Differentiation, and Memory

1. What event initiates an adaptive immune response?

A. The interaction of a B cell with a TH cell
B. The expression of cytokines CD4 or CD8
C. The production of MHC class I or II molecules
D. The interaction of a naïve T cell with an antigen-presenting cell
E. The phagocytosis of a pathogen by a macrophage

Answer: D
Section: Introduction
Difficulty: 1
Hint: T-cell activation

2. For pathogen peptides to be seen as foreign, they must be displayed on a T cell in the context of a/an:

A. B-cell marker.
B. CD molecule.
C. IgM molecule.
D. MHC peptide.
E. pattern-recognition receptor molecule.

Answer: D
Section: Introduction
Difficulty: 1
Hint: T-cell activation

3. CD4+ T cells recognize:

A. CD8+ markers.
B. IgM.
C. MHC class I peptides.
D. MHC class II peptides.
E. both MHC class I and class II peptides.

Answer: D
Section: Introduction
Difficulty: 1
Hint: TH cells

4. CD8+ T cells exposed to MHC class I peptides are:

A. cytotoxic T cells.
B. helper T cells.
C. both cytotoxic T cells and helper T cells.
D. natural killer cells.
E. dendritic T cells.

Answer: A
Section: Introduction
Difficulty: 1
Hint: TC cells

5. CD4+ T cells become helper T cells in response to:

A. exposure to antigen.
B. exposure to MHC class II peptide.
C. exposure to any MHC peptide.
D. exposure to MZ B cells.
E. exposure to TNF-α.

Answer: B
Section: Introduction
Difficulty: 1
Hint: TH cell activation

6. Naïve CD4+ and CD8+ T cells leave the ______ and enter circulation.

A. bone marrow
B. liver
C. lymph node
D. spleen
E. thymus

Answer: E
Section: T-Cell Activation and the Two-Signal Hypothesis
Difficulty: 1
Hint: Site of T-cell development

7. A naïve T cell refers to a T cell that:

A. does not express CD4+ or CD8+.
B. has not left the bone marrow.
C. has not yet encountered an antigen.
D. is not mature.
E. resides in the thymus.

Answer: C
Section: T-Cell Activation and the Two-Signal Hypothesis
Difficulty: 1
Hint: T-cell activation

8. Bonds formed between the T cell and a dendritic cell are relatively weak. Which of the following help to strengthen this association so that a T cell can see which antigen is being presented by a dendritic cell?

A. CD28/LFA-5
B. CD 28
C. ICAM-1/LFA-1
D. IL-2R
E. Pattern-recognition molecules

Answer: C
Section: T-Cell Activation and the Two-Signal Hypothesis
Difficulty: 2
Hint: T-cell co-receptors

9. Which of the following is required for T-cell activation?

A. Antigen-specific TCR binding to MHC peptide
B. Expression of CD4+ or CD8+
C. Interaction with CD80, CD86, or ICOS-L
D. Both A and B
E. Both A and C

Answer: E
Section: T-Cell Activation and the Two-Signal Hypothesis
Difficulty: 3
Hint: T-cell activation and T-cell co-receptors

10. Co-receptor molecules are required by TC and TH cells so that the TCR can stably bind to the MHC peptide presenting the antigen. Which co-receptor molecules are common to both TC and TH cells and their respective antigen presenting cells?

A. CD2/LFA-3
B. CD28/B7
C. CD45R/CD22
D. LFA-1/ICAM-1
E. All but B

Answer: E
Section: T-Cell Activation and the Two-Signal Hypothesis
Difficulty: 2
Hint: T-cell co-receptors