Chapter 11: Antimicrobial Drugs
VanMeter: Microbiology for the Healthcare Professional, 2nd Edition
1.The findings of the antibacterial properties of Penicillium notatum were first published by
ANS: D REF: p. 215
2.Prontosil, a dye, was first used as an antibiotic by
ANS: B REF: p. 215
3.All of the following are general metabolic or structural targets for antimicrobial drugs except
a. Lipid synthesis inhibition
b. Protein synthesis inhibition
c. Interference with nucleic acid synthesis
d. Interference with cell wall synthesis
ANS: A REF: p. 216
4.Which of the following is not a common characteristic used in the selection of an antimicrobial drug?
a. Selective toxicity
b. Ease of delivery to the site of infection
c. Ability to administer intravenously
d. Potential for allergic reaction
ANS: C REF: p. 217
5.The term bacteriostatic means that bacteria
a. are killed by the antimicrobial drug.
b. show continuous growth.
c. no longer can multiply.
d. no longer cause disease.
ANS: C REF: p. 218
6.Drugs that are effective against gram-positive and gram-negative bacteria, but not all of them, are ________ activity drugs.
ANS: C REF: p. 218
7.Which of the following is not a test to determine the efficacy of an antimicrobial agent against a specific organism?
a. Polymerase chain reaction
b. Kirby-Bauer method
c. Minimal inhibitory concentration method
d. Serum killing power method
ANS: A REF: p. 219
8.When two antibiotics are given together to increase the therapeutic effect, the phenomenon is referred to as
ANS: C REF: p. 219
9.Antimicrobial drugs that adversely affect the red bone marrow are referred to as
ANS: B REF: p. 220
10.All of the following are mechanisms of resistance used by microbes except
a. Change in ribosome composition
b. Development of defensive enzymes
c. Increased drug elimination
d. Change in membrane permeability
ANS: A REF: p. 222
11.Which of the following is a synthetic antimicrobial drug?
a. Penicillin G
b. Penicillin V
ANS: D REF: p. 224
12.Cephalosporins have __________ generations of developed agents.
ANS: D REF: p. 225