Human Heredity Principles And Issues 11th Edition By Michael Cummings – Test Bank

Human Heredity Principles And Issues 11th Edition by Michael Cummings – Test Bank

Chapter No: 11

True / False

1. When the number of trinucleotide repeats in a gene is significantly above normal, it can produce a mutant phenotype.

	a.	True
	b.	False

ANSWER:	True
DIFFICULTY:	Bloom’s: Understand
REFERENCES:	11-5 Mutations at the Molecular Level: DNA as a Target
LEARNING OBJECTIVES:	HUHE.CUMM.16.11-5-2 – Describe the phenomenon and characteristics of allelic expansion.

2. Nonsense mutations change termination codons into amino acid codons.

	a.	True
	b.	False

ANSWER:	False
DIFFICULTY:	Bloom’s: Understand
REFERENCES:	11-5 Mutations at the Molecular Level: DNA as a Target
LEARNING OBJECTIVES:	HUHE.CUMM.16.11-5-1 – Define the terms nucleotide substitution and frameshift mutation, and describe the different types and possible consequences of each.

3. PBDEs have not been linked directly to cancer in test animals.

	a.	True
	b.	False

ANSWER:	True
DIFFICULTY:	Bloom’s: Remember
REFERENCES:	11-1 Are Some Flame Retardants Dangerous?
LEARNING OBJECTIVES:	HUHE.CUMM.16.11-1-1 – Identify polybrominated diphenyl ethers (PBDEs) and list their possible negative health effects on humans and other animals.

4. Halogen-containing organic compounds persist in the environment for approximately five years.

	a.	True
	b.	False

ANSWER:	False
DIFFICULTY:	Bloom’s: Understand
REFERENCES:	11-1 Are Some Flame Retardants Dangerous?
LEARNING OBJECTIVES:	HUHE.CUMM.16.11-1-1 – Identify polybrominated diphenyl ethers (PBDEs) and list their possible negative health effects on humans and other animals.

5. A mutation of an autosomal recessive trait can remain undetected for generations.

	a.	True
	b.	False

ANSWER:	True
DIFFICULTY:	Bloom’s: Understand
REFERENCES:	11-3 Detecting Mutations and Measuring Mutation Rates
LEARNING OBJECTIVES:	HUHE.CUMM.16.11-3-1 – Describe how pedigree analyses are used by geneticists to determine the origin of an abnormal phenotype, and explain why it is difficult to identify the source of an autosomal recessive mutation.

6. Mutations in germ cells are passed on only to other germ cells in members of future generations.

	a.	True
	b.	False

ANSWER:	False
DIFFICULTY:	Bloom’s: Understand
REFERENCES:	11-2 Mutations Are Heritable Changes in DNA
LEARNING OBJECTIVES:	HUHE.CUMM.16.11-2-1 – Identify types of mutations and differentiate mutations that occur in somatic cells from those that occur in germ cells.

7. Most often, radiation doses are expressed in terms of damage.

	a.	True
	b.	False

ANSWER:	True
DIFFICULTY:	Bloom’s: Understand
REFERENCES:	11-4 Mutations Can Be Spontaneous or Induced
LEARNING OBJECTIVES:	HUHE.CUMM.16.11-4-1 – Examine the causes of mutations and classify the types of mutations associated with each cause.

8. Control systems in the cell can induce cell suicide, or apoptosis, in cells with excessive DNA damage.

	a.	True
	b.	False

ANSWER:	True
DIFFICULTY:	Bloom’s: Remember
REFERENCES:	11-6 Mutations Can Be Repaired
LEARNING OBJECTIVES:	HUHE.CUMM.16.11-6-1 – Explain the three possible fates of cells that accumulate significant DNA damage.

9. People with cystic fibrosis display a single phenotype for the disorder.

	a.	True
	b.	False

ANSWER:	False
DIFFICULTY:	Bloom’s: Understand
REFERENCES:	11-7 Mutations, Genotypes, and Phenotypes
LEARNING OBJECTIVES:	HUHE.CUMM.16.11-7-1 – Using cystic fibrosis as an example, demonstrate how the types and numbers of mutations that occur in a single gene can produce a wide range of disease phenotypes.

10. Beckwith-Wiedemann syndrome is a cell growth disorder that causes enlarged organs, high birth weight, and predisposition to cancer.

	a.	True
	b.	False

ANSWER:	True
DIFFICULTY:	Bloom’s: Remember
REFERENCES:	11-8 Epigenetic Changes Involve Reversible Alterations to the Genome
LEARNING OBJECTIVES:	HUHE.CUMM.16.11-8-3 – Illustrate the effects of abnormal genetic imprinting using Beckwith-Wiedemann syndrome as an example.

Human Heredity Principles And Issues 11th Edition By Michael Cummings – Test Bank