Hematology in Practice 2nd Edition By Betty Ciesla – Test Bank

Chapter 11: Acute Leukemias

Multiple Choice
Identify the choice that best completes the statement or answers the question.

____ 1. The basic pathophysiology mechanism responsible for producing signs and symptoms in leukemia includes all of the following except:
a. Replacement of normal marrow precursors by leukemic cells
b. Decrease in functional leukocytes causing infection
c. Hemorrhage secondary to thrombocytopenia
d. Decreased erythropoietin production

____ 2. Migration to extramedullary sites is a feature of which of the following leukemias?
a. Acute progranulocytic leukemia
b. Acute myelocytic leukemia
c. Acute monocytic leukemia
d. Acute lymphocytic leukemia

____ 3. A patient presents with generalized lymphadenopathy and a WBC of 100  109/L. This hematologic picture would most likely be seen in:
a. Chronic lymphocytic leukemia
b. Acute lymphocytic leukemia
c. Burkitt’s lymphoma
d. Hairy cell leukemia

____ 4. A patient with AML is likely to have a cytochemical stain panel that is positive for:
a. Sodium fluoride with tartrate resistance
b. MPO, SBB, specific esterase
c. MP0, SBB, nonspecific esterase
d. SBB and TdT

____ 5. The monoclonal marker that is often positive in T-ALL is:
a. CD1
b. CD7
c. CD10
d. CD41

____ 6. The t(15:17)(q22;q12) is associated with which of the following leukemias?
a. Acute promyelocytic leukemia
b. Acute myelomonocytic leukemia
c. Acute lymphocytic leukemia
d. Acute myelocytic leukemia

____ 7. The WBC count is 20  109/L, with 89% blasts, 7% segs, and 4% monos. The blasts are relatively large and have abundant cytoplasm. More than 90% of them are positive with the NSE stain, and an occasional blast is positive with Sudan Black B. What is the possible diagnosis?
a. AML, type M1
b. AML, type M3
c. AML, type M4
d. AML, type M5

____ 8. The L3 classification of leukemia is defined by:
a. Small homogeneous blasts
b. Large vacuolated blasts
c. Large heterogeneous blasts
d. Predominance of prolymphocytes

____ 9. Acute leukemic processes are marked by:
a. Slow onset, slow progression, anemia
b. Rapid onset anemia, thrombocytopenia
c. Splenomegaly
d. Less than 30% in the BM

____ 10. Which of the following is characteristic of Auer rods?
a. Composed of fused primary granules
b. Predominantly seen in ALL
c. Predominantly seen in HCL
d. Composed of specific granules